Central Precocious Puberty in Boys and Girls: Similarities and Differences

Central precocious puberty (CPP) is due to the premature activation of hypothalamic–pituitary–gonadal axis, which responsible for appearance secondary sexual characteristics. It occurs before age 8 and 9 in girls boys, respectively. CPP shows higher incidence females than males. Causes are similar both sexes, but idiopathic form more frequent girls, while organic forms Recent studies demonstrated a role some genetic variants pathogenesis CPP. The diagnostic evaluation based on accurate physical examination, assessment pituitary–gonadal pelvic sonography determination bone age. Magnetic resonance central nervous system should be done all boys selected girls. Since 1980s, pharmacologic treatment involves use gonadotropin-releasing hormone (GnRH) analogs. These drugs characterized by few side effects long-term safety. Many data available outcome GnRH analog treated female patients, poor reported boys. Adult height improved sexes.